孕妇患有皮佩拉西林/塔扎巴克坦诱导的可逆性泛细胞衰竭:一个病例报告
International journal of clinical pharmacology and therapeutics
|December 30, 2025
概括
皮佩拉西林/塔扎巴克坦,在怀孕期间被认为是中等安全的,可能会导致胰岛素减肥. 本病例报告详细介绍了一名患有这种不良反应的孕妇患者,强调了怀孕期间的潜在风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
背景情况:
- 皮佩拉西林/塔扎巴克坦通常被认为是B类妊娠,不常见的血液学副作用 (<1%) 主要发生在非怀孕的成年人中.
- 怀孕引起的药理动力学变化可能会影响药物毒性值.
- 怀孕期间的囊需要抗生素治疗,需要仔细选择药物.
研究的目的:
- 在怀孕的患者中报告第一个皮佩拉西林/塔扎巴克坦诱导的全细胞衰竭病例.
- 为了突出怀孕期间与皮佩拉西林/塔扎巴克坦使用相关的潜在血液风险.
主要方法:
- 一个26周怀孕的患者的案例研究,用皮佩拉西林/塔扎巴克坦治疗由Proteus mirabilis引起的psoas.
- 在抗生素治疗期间和之后监测血液学参数和不良事件.
- 使用Naranjo尺度来评估药物不良反应的因果关系.
主要成果:
- 患者经过22天的piperacillin/tazobactam治疗后出现了轻度发烧,白血病,中性质衰竭和血小板衰竭.
- 在停止服用抗生素三天后,血液学参数恢复正常.
- 纳兰乔尺度得分为7的得分表明了明确的药物不良反应.
结论:
- 皮佩拉西林/塔扎巴克坦可以在怀孕期间诱导胰岛素减肥,这是一个罕见但严重的不良反应.
- 临床医生应密切监测孕妇的血液学变化时,处方piperacillin/tazobactam.
- 这一案例强调了在怀孕期间考虑药物的药理动力学变化和潜在的毒性的重要性.
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