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Updated: Jan 7, 2026

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用于双等效抑制剂的多种链接器进行BET异形选择性:GSK785是一种BRD2/4-选择性双等效BET抑制剂

Francesco Rianjongdee1, Stephen J Atkinson1, Paul Bamborough1

  • 1GSK, Stevenage, Hertfordshire SG1 2NY, U.K.

Journal of medicinal chemistry
|December 30, 2025
PubMed
概括

研究人员开发了新的双价抑制剂,向和额外终端 (BET) 蛋白质. 他们发现了GSK785,这种分子可以选择性抑制BRD2和BRD4,同时节省BRD3,为改善癌症治疗提供了潜在的潜力.

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