血清尿酸水平和老年人认知功能的纵向变化:基于性别分层的基于人口的研究
Md Golam Rabbani1, Sheikh M Alif1,2, Joanne Ryan1
1School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, VIC, Australia.
概括
低血清尿酸 (SUA) 水平与老年女性的认知能力下降有关,特别是全球认知和情节性记忆. 在男性或高SUA水平的人群中没有发现这种关联.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 血清尿酸 (SUA) 与认知功能有关,但性别特异性需要研究.
- 荷尔蒙和脏因素在SUA水平中产生生物性别差异,需要进行性别分层分析.
- 以前的研究还没有完全阐明SUA与老年人认知变化之间的关系.
研究的目的:
- 检查血清尿酸 (SUA) 水平与老年人随时间变化的认知功能之间的关联.
- 进行性别分层分析,以确定SUA-认知关系是否在男性和女性之间有所不同.
- 研究SUA水平对全球认知,情节性记忆,执行功能,口语流和精神运动速度的影响.
主要方法:
- 利用了来自11,411名社区居民参与阿司匹林减少老年人事件 (ASPREE) 研究的数据.
- 使用修改型迷你心理状态检查 (3MS),霍普金斯口语学习检查修订 (HVLT-R),符号数字模式测试 (SDMT) 和控制口语词汇协会测试 (COWAT) 评估认知功能,平均9年.
- 为男性和女性使用单独的线性混合效应回归模型来分析SUA与认知变化的关联.
主要成果:
- 在女性中,最低的SUA五分位数 (Q1) 与全球认知 (3MS) 和情节性记忆 (HVLT-R延迟回忆) 的下降有显著关联.
- 最高的SUA五分位数 (Q5) 没有显示与女性认知能力下降的相关性.
- 在所有测试的认知领域中,在男性中没有观察到SUA水平和认知功能变化之间的显著关联.
结论:
- 低血清尿酸 (SUA) 水平与老年女性的全球认知和情节性记忆的认知下降特别相关.
- 血清尿酸 (SUA) 水平与男性的认知能力下降或女性的SUA水平较高无关.
- 保持SUA水平在生理范围内的水平可能是支持认知健康的策略,特别是在老年女性中.
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