患有恶性瘤的儿科患者的登革热感染:单中心回顾性研究
Ragul Rajan Radha1, Binitha Rajeswari1, Prasanth Varikkattu Rajendran1
1Department of Pediatric Oncology.
Journal of pediatric hematology/oncology
|December 30, 2025
概括
登革热是癌症儿童发烧性中性质衰竭的关键诊断,即使没有典型的警告信号. 早期考虑改善了特有地区患者的治疗结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 发烧性中性质是儿童癌症患者的常见并发症.
- 登革热病毒感染可以呈现非特异性症状,模仿其他发烧性疾病.
- 早期和准确的登革热诊断对于免疫受损儿童的适当管理至关重要.
研究的目的:
- 评估儿童癌症患者登革热的临床表现和结果.
- 评估登革热在发烧性中性衰竭的差异诊断中的作用.
- 突出在流行地区考虑登革热的重要性,不管有什么警告信号.
主要方法:
- 对被诊断患有登革热的儿科患者 (年龄≤14岁) 的病历进行回顾性审核.
- 纳入标准:世卫组织2009年登革热标准和通过IgM或NS1检测确认.
- 分析症状,临床过程,实验室值和患者结果.
主要成果:
- 23名儿童癌症患者被诊断患有登革热;69%患有B级急性淋巴细胞白血病 (B-ALL).
- 超过一半 (56.6%) 患有没有预警症状的登革热;21.7%患有预警症状的登革热,21.7%患有严重的登革热.
- 化疗的中位延迟时间为6天;13%的患者患有血细胞性淋巴细胞瘤 (HLH). 一名患者死于多器官衰竭.
结论:
- 登革热应考虑在流行地区的儿科癌症患者发烧性中性质衰竭的差异诊断中.
- 即使没有经典的登革热预警信号,迅速识别和管理登革热是必不可少的.
- 登革热感染可以导致严重的并发症,如HLH和毒症在这个脆弱的人群.
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