Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

3.6K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.6K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

447
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
447

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Exploring risk factors associated with catastrophic health expenditure on diarrhea management in Karachi, Pakistan, 2022-2024.

PLOS global public health·2026
Same author

Impact of a clinical engagement targeted antimicrobial stewardship program on antimicrobial use in Pakistan: a multicenter longitudinal point prevalence survey.

Expert review of anti-infective therapy·2026
Same author

The consequences of <i>Shigella</i> medically-attended diarrhoea and other leading pathogens among young children living in high-burden settings: a multi-country prospective cohort study.

EClinicalMedicine·2026
Same author

Frequency and correlates of non-receipt of age-appropriate vaccination among children aged 6-35 months with medically attended diarrhea: Findings from the Enterics for Global Health (EFGH) Shigella study, 2022-2024.

PLOS global public health·2026
Same author

Pullback pressure gradients: Redefining the functional landscape of coronary artery disease.

Cardiovascular revascularization medicine : including molecular interventions·2026
Same author

The feasibility of promoting recreational physical activity to manage type 2 diabetes in urban Bangladesh: A qualitative study.

Global public health·2026

相关实验视频

Updated: Jan 7, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.7K

在Synovium中使用pH响应的纳米粒子进行向性胆固醇治疗.

Syeda Komal Fatima1, Naveed Ahmed1, Kainat Gul2

  • 1Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

Journal of biomaterials science. Polymer edition
|December 30, 2025
PubMed
概括

这项研究开发了针对性痛风治疗的新型Colchicine-EL-100-聚合物纳米颗粒,提供持续的,对pH反应的药物释放和减少炎症. 该配方对局部痛风管理具有较少系统性副作用的有希望.

关键词:
这是一种痛风,痛风.科尔奇辛 (Colchicine) 是一种可怕的药物.药物输送是药物输送的过程.纳米颗粒是一种纳米粒子.响应pH的pH值的响应通过皮肤通过皮肤.

更多相关视频

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.3K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K

相关实验视频

Last Updated: Jan 7, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.7K
Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

9.3K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K

科学领域:

  • 纳米技术纳米技术
  • 药理学 药理学是指药理学的学科.
  • 生物化学 生物化学

背景情况:

  • 传统的痛风疗法具有显著的全身不良影响,需要先进的药物输送系统.
  • 针对性和持续的治疗干预对于有效的痛风管理至关重要.
  • NLRP3炎症酶在痛风的发病过程中发挥着关键作用,使其成为一个可行的治疗点.

研究的目的:

  • 为了制定和表征Colchicine-EL-100-聚合物纳米颗粒用于pH依赖的药物释放.
  • 在实验性痛风模型中评估这些纳米颗粒的疗效.
  • 研究局部痛风治疗的潜力,降低全身毒性.

主要方法:

  • 使用Box-Behnken设计制备和优化聚合物纳米粒子.
  • 使用FTIR,XRD,DSC和FE-SEM进行物理化学表征.
  • 在MSU诱导的痛风模型中进行了体外释放,体外透和体内研究.

主要成果:

  • 分子对接表明,素与NLRP3.3的结合是有利的.
  • 优化的纳米粒子表现出良好的物理化学稳定性 (大小,泽塔潜力,EE%).
  • 观察到pH值依赖的释放,pH值为6.8时增强释放,pH值为7.4时限制释放.
  • 活体研究证实了皮肤透,而体内研究显示炎症和IL-6水平显著降低.

结论:

  • 科尔奇辛-EL-100-聚合物纳米颗粒为持续和向的痛风治疗提供了一个有希望的平台.
  • 响应pH的释放机制有助于局部药物输送.
  • 这种配方在治疗痛风方面具有显著的治疗潜力,并改善了安全性.