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作为认知和病理生理学大脑标志物的预测因素,心率变化的证据有限

Sofia Marcolini^1,2, Jaime D Mondragón^1,2,3,4, Arie M van Roon⁵

¹Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Journal of Alzheimer's disease : JAD

|December 30, 2025

概括

心率变化 (HRV) 并没有预测认知能力下降或阿尔茨海默病的生物标志物. 然而,在高冠状动脉化的个体中,13年前更高的HRV与较低的Aβ42 / Aβ40比率有关,这表明存在复杂的关系.

科学领域:

神经学神经学
心脏病学心脏病学
生物标志物生物标志物

背景情况:

心率变化 (HRV) 与认知功能有关,可能表明早期的阿尔茨海默病.
冠状动脉化是一种可能影响这种关系的心血管风险因素.

研究的目的:

调查HRV是否能预测阿尔茨海默病的认知和病理生理学大脑标志物.
要确定这些预测是否独立于冠状动脉化.

主要方法:

269名没有认知障碍的成年人被冠状动脉化分层 (缺席与高).
时间域HRV是在13年的两个时间点 (T0,T1) 测量.
认知,血清阿尔茨海默病生物标志物 (Aβ42/Aβ40) 和脑成像标志物在8-13年后被评估 (T3).

主要成果:

与没有结石化的参与者相比,高冠状动脉结石化的参与者具有较低的基线HRV,并且随着时间的推移有不同的HRV变化.
在高化组中,T0时较高的HRV与T3时较低的Aβ42/Aβ40比率有关.
在HRV (在T1或变化) 和认知或脑成像结果之间没有发现显著的关联.

结论:

HRV与阿尔茨海默病的认知或脑成像标志物没有直接关联.
在高冠状动脉化的个体中,13年前测量的HRV显示与与阿尔茨海默病相关的生物标志物有关.
在评估HRV作为认知衰退和阿尔茨海默病的预测因素时,必须考虑冠状动脉化状态.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.生物标志物生物标志物认知障碍认知障碍认知障碍痴呆症痴呆症是一种痴呆症.健康状况卫生状况心率变化的心率变化.

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