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Published on: June 11, 2012
在2型糖尿病中进行自动胰岛素输送的随机试验
Yogish C Kudva1, Dan Raghinaru, John W Lum
1Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN (Y.C.K., D.D., C.K.); Jaeb Center for Health Research, Tampa, FL (D.R., J.W.L., T.C., C.S., L.K., C.K., R.W.B.); Diabetes and Endocrine Treatment Specialists, Sandy, UT (T.E.G., A.N.T., R.D.L.); Rocky Mountain Clinical Research, Idaho Falls, ID (D.L.); Division of Endocrinology, Diabetes, and Nutrition, Baltimore VA Medical Center, Baltimore, MD (E.K.S., L.G.S., J.C.); Division of Endocrinology, Emory University School of Medicine, Emory University, Atlanta, GA (F.J.P., G.M.D., F.Z.T.); Harold Schnitzer Diabetes Health Center, Oregon Health and Science University, Portland, OR (A.A., C.S., A.D.); Mary and Dick Allen Diabetes Center, Hoag Memorial Hospital Presbyterian, Newport Beach, CA (D.T.A., B.D.); Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (G.A., J.K., K.C., E.F.); Texas Diabetes and Endocrinology, Austin, TX (T.B., L.C., V.E., J.P.); Division of Endocrinology, Henry Ford Health System, Detroit, MI (D.K., J.K.J., K.E., S.M.); Division of Endocrinology, Center for Diabetes Technology, University of Virginia, Charlottesville, VA (S.A.B., S.A., J.D.); Division of Endocrinology, Icahn School of Medicine at Mount Sinai, New York (C.J.L., C.L., G.O., A.I.); and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, SUNY Upstate Medical University, Syracuse (R.S.W., S.B.), NY; Boston Medical Center, Boston, MA (D.W.S., A.A.C.); Division of Endocrinology, St Joseph's Health Care, Lawson Health Research Institute, London, Ontario, Canada (T.S., S.L.L., M.D.); University of Washington School of Medicine, Seattle (I.B.H., X.A.); and Rainier Clinical Research Center, Renton (F.B., S.M.), WA; Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (M.R.R., A.J.P., C.V.D.-B.); Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada (M.A.T., M.-R.P., V.T., A.M.); UT Southwestern Medical Center, University of Texas, Southwestern, Dallas, TX (P.R., L.F.J.); University Hospitals Cleveland Medical Center, Cleveland, OH (B.H., A.L.); and Tandem Diabetes Care, San Diego, CA (J.E.P., R.S.-K.).
自动化胰岛素输送系统 (AID) 显示出对2型糖尿病的管理有前途,特别是对于那些无法通过其他药物达到血糖目标的人来说. 需要进一步的研究来确认它在这个人群中的好处.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 医疗技术 医疗技术 医学技术
背景情况:
- 自动化胰岛素输送 (AID) 系统是为1型糖尿病管理而建立的.
- 由于研究有限,AID在2型糖尿病 (T2DM) 的疗效尚不清楚.
- 一些T2DM患者无法通过GLP-1激动剂或SGLT-2抑制剂等当前疗法实现血糖控制.
研究的目的:
- 评估AID系统对T2DM患者的潜在好处.
- 探索AID作为对T2DM患者的治疗选择,这些患者不能达到血糖目标.
主要方法:
- 对T2DM中AID现有研究的审查.
- 对没有响应标准T2DM药物治疗的患者群体的分析.
- 使用AID与传统管理的T2DM患者的结局的比较.
主要成果:
- 有限的研究表明T2DM中可能有AID.
- 其他治疗方法失败的患者可能会从AID中获益.
- 需要进一步进行受控试验,以确定疗效和安全性.
结论:
- 辅助系统可以为选择的T2DM患者提供有价值的治疗选择.
- 需要更强大的临床试验来确认AID在T2DM管理中的作用.
- 艾滋病治疗可以改善对其他治疗不耐药的T2DM患者的血糖控制.
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