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Updated: Jun 27, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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Published on: July 6, 2013

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对于CMV初级感染的产前查:一个成本效益模型

Gebrael El Hachem1, Christian Renaud, Catherine McCarey

  • 1School of Public Health, Université de Montréal (G.E.H., T.G.P., I.B.); Women and Children's Infectious Diseases Center, CHU Sainte-Justine Research Center (G.E.H., C.R., C.M., S.G., F.K., I.B.); Research Center of the IUSMM, CIUSSS de l'Est de l'Île de Montréal (T.G.P.); and Departments of Obstetrics and Gynecology (C.M.) and Pediatrics (C.R., S.G., F.K.), Université de Montréal, Montreal, Quebec, Canada; and Faculty of Medicine, Université Catholique de Louvain, Brussels, Belgium (M.S.).

Obstetrical & gynecological survey
|December 30, 2025
PubMed
概括

先天性细胞巨乳病毒 (cCMV) 影响了大约每200名加拿大新生儿中的1名. 这种感染可以导致儿童严重的神经发育障碍.

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Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...