艾滋病毒感染者的表观遗传年龄加速和脆弱性
Krisann K Oursler1,2, Yan V Sun3,4, Alicia J Lozano5
1Department of Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.
AIDS research and human retroviruses
|December 30, 2025
概括
表观遗传年龄加速 (EAA) 标志物,特别是GrimAge加速,与艾滋病毒感染者 (PWH) 的脆弱性有关. 这表明EAA可能有助于为PWH量身定制脆弱性治疗.
科学领域:
- 表观遗传学和衰老研究.
- 艾滋病毒/艾滋病和衰老研究
- 老年学和脆弱性研究研究.
背景情况:
- 基因甲基化是生物衰老的一个关键指标.
- 在艾滋病毒感染者 (PWH) 中,表观遗传衰老加速 (EAA) 和虚弱是常见的,但它们之间的关系尚不清楚.
- 了解EAA在脆弱性中的作用对于开发针对老化PWH的有针对性的干预措施至关重要.
研究的目的:
- 调查EAA标志物与艾滋病毒感染者 (PWH) 的脆弱性之间的关联.
- 确定EAA是否可以独立于传统风险因素来预测脆弱性.
- 根据EAA. 探索基于PWH脆弱性的潜在治疗点.
主要方法:
- 使用退伍军人衰老队列研究 (VACS) 数据的观察性研究.
- 用四个表观遗传时钟 (Horvath,Hannum,PhenoAge,GrimAge) 分析了整个表观基因组的DNA甲基化数据,以获得EAA标记.
- 使用验证的VACS脆弱性相关表型评估脆弱性;用于测试关联的后勤回归.
主要成果:
- 在研究的1,076名PWH中,有36.9%的人患有脆弱性.
- 灰色年龄加速 (GrimAA),色年龄加速 (PhenoAA) 和色年龄加速 (HannumAA) 与脆弱性有显著的关联.
- GrimAA独立地与45%的虚弱率增加有关 (ORadj: 1.45) 并显示与运动频率的联系.
结论:
- 选择EAA标记物,特别是GrimAA,与PWH的脆弱性有关,独立于传统预测器.
- GrimAA可以作为一种有价值的生物标志物,用于识别患有脆弱性风险较高的PWH.
- 未来的研究可以利用GrimAA开发针对PWH的个性化脆弱性管理策略.
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