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在国家质量计划中对总胆红素的评估

Lauren E H Westenberg¹, Marith van Schrojenstein Lantman^2,3, Miranda van Berkel^2,3

¹Division of Neonatology, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Clinical chemistry

|December 30, 2025

概括

新生儿胆红素测量显示了不同分析方法和平台的显著偏差和变化. 外部质量评估 (EQA) 计划对于监测这些测试和确保婴儿黄的准确诊断至关重要.

科学领域:

临床化学临床化学
实验室医学实验室医学
新生儿健康新生儿健康

背景情况:

准确的新生儿胆红素量化是一个持续的临床挑战.
外部质量评估 (EQA) 计划监测荷兰医院总胆红素测量的分析性能.

研究的目的:

分析新生儿胆红素测量偏差和变化的趋势.
评估不同分析原理,制造商和平台的性能.

主要方法:

对2013-2025年荷兰EQA数据的回顾性分析.
来自81个实验室的25983个胆红素测量的评估,使用聚合的血清样本.
从参考测量程序和变化系数 (CV) 评估偏差.

主要成果:

基于Diazo和光谱仪的方法显示了最低的中位偏差.
基于Vanadate的方法显示出显著的偏差,因因子化减少.
偏差因制造商,平台和 bilirubin 度而异,CVs 一般低于 5%.

结论:

在新生儿胆红素测定系统中存在偏差的时间变化.
为了可靠的测量,急需对新生儿胆红素测定进行标准化.
对于监测测定性能和管理新生儿高 bilirubinemia,EQA 程序至关重要.

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