全免疫炎症值与可能的抑郁症之间的关系中的性别差异:一个横截面研究
Dongdong Yu1, Ting Cheng1,2, Yue Yang2
1Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
PloS one
|December 30, 2025
概括
升高的泛免疫炎症值 (PIV) 与更高的可能抑郁症风险有关,特别是在女性中. 这种炎症标志物显示出与抑郁症的性别特异关联,需要进一步调查潜在机制.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 全免疫炎症值 (PIV) 是一个反映系统性炎症的新兴生物标志物.
- 抑郁症是一种普遍存在的心理健康状况,具有复杂的潜在因素.
- 了解炎症和抑郁之间的关系对于开发有效的干预措施至关重要.
研究的目的:
- 调查PIV和可能的抑郁症之间的非线性关联.
- 为了确定与抑郁风险相关的PIV的潜在值.
- 探索PIV与抑郁症关系中的性别特异性差异.
主要方法:
- 利用了2005-2018年国家健康和营养检查调查 (NHANES) 的数据 (n=27,049).
- 采用受限立方线分析来建模非线性关系并确定最佳的PIV切线.
- 进行了加权后勤回归和性别分层分析,以评估PIV与可能的抑郁症的关联.
主要成果:
- 确定了5.74的最佳PIV截止值.
- 具有PIV> 5.74的个体表现出14%的可能抑郁症风险增加 (OR=1.14,95% CI:1.02-1.28)
- 在女性中观察到显著的关联 (OR=1.20,95% CI:1.03-1.40),但在男性中没有. 在男性中,PIV与年龄,教育和酒精消耗相互作用.
结论:
- PIV可以作为可能抑郁风险的性别特异性生物标志物.
- 在女性中,PIV和可能的抑郁症之间的关联似乎更强大.
- 需要进一步的研究来澄清这些性别差异背后的机制,并验证临床使用的发现.
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