肠道微生物群的特征与儿科耐药性的基因饮食反应相关
Yao Wang1, Jing Guo1, Peiqi Zhang1
1Department of Neurology, Guangdong Sanjiu Brain Hospital, Guangzhou 510000, Guangdong Province, China.
肠道细菌Lachnoclostridium和Barnesiella可能预测性饮食 (KD) 在患有耐药性 (DRE) 的儿童中的成功. 在KD期间的Parabacteroides和Akkermansia的变化也表明了治疗反应.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 肠道微生物群越来越多地被认可为其在调解性饮食 (KD) 影响中的作用.
- 预测性微生物生物标志物用于KD治疗耐药性 (DRE) 尚未明确定义.
- 了解这些生物标志物可以帮助个性化DRE治疗.
研究的目的:
- 确定与儿科DRE患者对KD治疗反应相关的肠道微生物群特征.
- 为了研究预测KD疗效的特定细菌属.
- 探索KD干预期间肠道微生物群组成的动态变化.
主要方法:
- 对42名儿科DRE患者 (2-10岁) 进行前性研究,这些患者接受了KD治疗.
- 在基线和多个时间点收集的便样本,长达6个月.
- 用于分析肠道微生物群组成的16S rRNA基因测序.
- 治疗反应定义为3个月后发作减少≥50%.
主要成果:
- 受访者 (n=16) 显示出较高的基线Lachnoclostridium和Barnesiella丰度.
- 干预后,KD响应者表现出增加的Parabacteroides和Akkermansia水平.
- 没有反应的人始终有更高的Catenibacterium水平.
- 在KD治疗一个月后,在响应者中观察到升高的Parabacteroides.
结论:
- 基线时的Lachnoclostridium和Barnesiella是儿科DRE中KD反应的潜在预测生物标志物.
- 在KD期间Parabacteroides和Akkermansia的动态增加区分了响应者.
- 增加的Catenibacterium与KD的不良结果有关,有助于治疗分层.
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