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在肌工程中,冷干燥和印制的原体支架
Ignacio Sallent1, Lefki Chaniotaki2, Dimitrios I Zeugolis3
1Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) and CÚRAM Research Ireland Centre for Medical Devices, University of Galway, Galway, Ireland.
Biomaterials advances
|December 30, 2025
概括
本综述探讨了用于肌修复的I型原体支架. 先进的制造和交叉连接方法为肌工程创造了精确,硬和兼容的支架.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- I型原蛋白是肌中的主要结构蛋白.
- 开发有效的支架对于肌修复和再生至关重要.
- 现有的方法需要优化,以精确控制脚手架属性.
研究的目的:
- 审查用于肌工程的原体支架制造方面的进展.
- 讨论增强支架特性 (如刚性和细胞相容性) 的策略.
- 为了评估冷干燥和印制的原体支架的有效性.
主要方法:
- 审查用于脚手架制造的冷干燥技术.
- 软石版的分析,用于精确的建筑控制.
- 对机械和生物调节的原交叉连接策略的概述.
主要成果:
- 冷干燥和软光刻法使得可制造具有定义架构的原体支架.
- 交叉连接策略提高了支架的刚性和细胞相容性.
- 冷干燥和印制的原基架在肌工程应用中显示出希望.
结论:
- 先进的制造技术是创建功能性的原体支架的关键.
- 优化交叉连接对于定制脚手架性能至关重要.
- 通过这些方法生产的原基架代表了肌修复策略的重大进步.
相关概念视频
Curing Methods
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
Drying Shrinkage
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
A portion of this drying shrinkage can be reversed; if the concrete is...

