竹叶的黄类化合物通过微生物群和代谢重编程来抵消老龄化产母的脂聚糖诱导的肠道功能障碍
Xinyu Shen1, Weichen Huang2, Shenao Zhan2
1Hainan Institute, Zhejiang University, Sanya 572000, China; Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Poultry science
|December 30, 2025
概括
竹叶黄酸 (BLF) 保护老年免受脂聚糖 (LPS) 引起的肠道损伤. BLF改善了肠道屏障功能,减少了炎症,并积极改变了肠道微生物群和新陈代谢,提高了家禽的弹性.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物营养 动物营养
- 胃肠病学 胃肠病学
背景情况:
- 老龄化产卵母由于生理衰退和肠道微生物群不平衡而增加了肠道损伤.
- 细菌性脂多糖 (LPS) 在老年家禽中加剧肠道损伤.
- 竹叶黄素 (BLF) 具有已知的抗炎和免疫调节特性.
研究的目的:
- 为了研究BLF对肠道屏障功能,炎症反应和老化产卵母的肠道微生物群的影响,这些产卵母受到LPS的挑战.
- 评估BLF在缓解LPS引起的肠功能障碍方面的潜力.
主要方法:
- 360只养被分为对照,BLF,LPS和BLF+LPS组.
- 评估了状的结构,肠道屏障功能和透性.
- 分析了脑内微生物群的组成,并进行了非向的代谢.
主要成果:
- 补充BLF改善了对照的阴形态和屏障功能.
- 这种LPS挑战诱导了小缩,屏障功能障碍和炎症.
- BLF通过恢复状结构,增强屏障功能和抑制炎症来改善LPS诱导的肠道功能障碍.
- BLF调节了内微生物群,减少了致病性种类,增加了像Lactobacillus这样有益的属.
- 代谢学揭示了BLF纠正的氨基酸和胆酸通路中的LPS诱导的干扰.
结论:
- 在老年中,BLF减轻了LPS诱导的肠功能障碍.
- BLF增强了肠道屏障的完整性,减少了炎症,重塑了肠道微生物群,并重新编程了新陈代谢.
- BLF显示出作为料添加剂的潜力,以改善在炎症压力下家禽的肠道弹性.
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