饮食中的纳米皮科林酸盐增强了针对纽卡斯尔病接种疫苗的热应激肉的干扰素-马表达
Farhad Hajializadeh1, Alireza Talebi2, Raziallah Jafari Jozani3
1Graduate student, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
Research in veterinary science
|December 30, 2025
概括
饮食纳米皮科林酸盐 (Nano-CrPic) 补充剂在接种疫苗后增强热应激肉的细胞免疫力. 这改善了疫苗的反应,这对于热应激期间的家禽健康至关重要.
科学领域:
- 禽类免疫学 禽类免疫学
- 动物营养动物营养
- 环境压力生理学环境压力生理学
背景情况:
- 热应激 (HS) 对家禽免疫力和疫苗有效性产生负面影响.
- 纽卡斯尔病 (ND) 疫苗接种对于肉健康至关重要.
- 细胞免疫力,特别是干扰素- (IFN-γ) 生产,对于疫苗反应至关重要.
研究的目的:
- 评估 (III) 皮科林酸盐 (CrPic) 和其纳米配方 (纳米-CrPic) 在减轻热应激对 brojler 细胞免疫力的有效性.
- 确定CrPic和Nano-CrPic对受热应激条件下的疫苗接种肉的IFN-γ mRNA表达的影响.
主要方法:
- 罗斯308肉被持续地暴露在热中.
- 鸟类接受了500,1000或1500ppb的CrPic或Nano-CrPic食补充剂.
- 接种了纽卡斯尔病疫苗,在接种疫苗后,在脏组织中量化了IFN-γ mRNA的表达.
主要成果:
- 与对照组相比,接种疫苗的肉的IFN-γ表达显著增加.
- 在热应力下补充纳米CrPic (500和1000ppb) 与热应力对照相比,IFN-γ的表达增加了35-50%.
- 与传统的CrPic相比,Nano-CrPic显示出更优异的结果,在1500ppb时观察到非线性剂量反应.
结论:
- 食纳米CrPic在500-1000ppb有效地改善了接种疫苗,热应激肉的细胞免疫反应.
- 纳米-CrPic提供了一种实际的策略,以提高面临热应激的家禽的疫苗疗效.
- 这种补充可以加强免疫系统在具有挑战性的环境条件下对疫苗接种的反应能力.
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