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尿液枯竭通过N-糖基化减弱了CD8+T细胞的抗瘤活性

Jianbiao Xiao1, Zhiyang Li2, Yi Ding3

  • 1Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong , China; Jinfeng Laboratory, Chongqing, China.

Cell metabolism
|December 30, 2025
PubMed
概括

免疫检查点阻塞 (ICB) 抵抗与SNX17有关. 降低SNX17或添加尿素可以增强抗瘤免疫力,提供一种新的治疗策略.

关键词:
在 CD8+ T 细胞中.在N-glycosylation的过程中.在SNX17上.UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1 UPP1检查站封锁检查站封锁免疫疗法耐药性 免疫疗法耐药性尿素 尿素 尿素

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