CircTarget:一个全面的数据库,包含跨多种细胞类型的circRNA-目标RNA相互作用
Hongmei Zhang1,2,3, Yuyang Zhang4, Peng Li2
1Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510100, China.
Nucleic acids research
|December 30, 2025
概括
循环RNAs (circRNAs) 是关键的基因调节剂,但它们的点是未知的. CircTarget是一个新的数据库,以高分辨率映射成千上万个经过实验验证的circRNA-目标RNA相互作用.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 循环RNAs (circRNAs) 是普遍存在的调节分子,其来源于mRNA前的逆拼接.
- circRNAs在基因调节和疾病发展中起着至关重要的作用.
- 识别circRNA目标是必不可少的,但仍然是该领域的一个重大挑战.
研究的目的:
- 开发第一个实验验证的circRNA-目标RNA相互作用的全面数据库.
- 提供这些相互作用的单核酸分辨率映射.
- 促进研究circRNA功能和疾病机制.
主要方法:
- 来自各种交叉连接方法的RNA-RNA交互原子数据的分析.
- 来自13个细胞系和人类/小鼠海马组织的数据集成.
- 使用严格的标准识别高可信度circRNA-目标RNA相互作用.
主要成果:
- 发现了132,517个高度可靠的circRNA-目标RNA相互作用.
- 开发CircTarget,这是一个数据库,每个交互都有详细的注释.
- 包括circRNA信息,疾病关联,相互作用部位和相关的遗传变异.
结论:
- CircTarget是探索circRNA功能和相互作用的宝贵资源.
- 该数据库提供了关于circRNA-目标RNA结合的实验支持的证据.
- 通过CircTarget,可以更深入地研究circRNAs在基因调节和疾病发病过程中的作用.
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