剖析严重精神障碍和自身免疫性疾病之间的遗传关系
Erik D Wiström1, Julian Fuhrer1, Alexey Shadrin1
1Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
严重的精神障碍,如严重抑郁症,与自身免疫性疾病有着共同的遗传联系. 这项研究揭示了明显的遗传重叠,表明了潜在的新型基于免疫的精神疾病治疗方法.
科学领域:
- 精神病学和免疫学 精神病学和免疫学
- 遗传学和流行病学
背景情况:
- 严重的精神障碍与免疫功能障碍有关.
- 精神障碍和自身免疫性疾病之间的确切遗传关系尚未得到充分理解.
研究的目的:
- 综合调查大抑郁症 (MD),双相情感障碍 (BD),精神分裂症 (SCZ) 和七种自身免疫性疾病之间共享的遗传结构.
- 确定特定的遗传位置和生物途径,涉及到这些疾病的共同遗传基础.
主要方法:
- 利用了来自10项全基因组关联研究的数据的补充统计分析,共计667,518例.
- 检查了MD,BD,SCZ和自身免疫性疾病之间的遗传相关性,包括自身免疫性甲状腺炎,腹病,炎症性肠病 (IBD),多发性硬化症,牛皮,类风湿性关节炎和1型糖尿病.
主要成果:
- 重度抑郁症与五种自身免疫性疾病具有积极的遗传相关性,而双相情感障碍和精神分裂症主要与IBD相关.
- 自免疫性疾病的遗传变异中很大一部分与精神障碍重叠,尽管这种重叠构成了多基因精神障碍遗传变异中很小的一部分.
- 确定了172个共同影响精神障碍和自身免疫疾病的基因位置,涉及脂质代谢和TNF信号通路.
结论:
- 大型抑郁症,双相情感障碍和精神分裂症与自身免疫性疾病具有很小但明显的遗传重叠.
- 这些发现表明,在治疗严重精神障碍方面,潜在的新型免疫点可能是严重精神障碍.
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