血蛋白质介导退行性关节疾病和痴呆风险之间的关联
Zijian Kang1, Jianzheng Zhang2, Chen Zhu3
1Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of advanced research
|December 30, 2025
概括
退行性关节疾病 (DJD) 显著增加痴呆风险,特别是血管性痴呆. 这种联系是由特定的血液蛋白质调解的,这表明炎症和血管问题是关键机制.
科学领域:
- 生物医学科学 生物医学科学
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 退行性关节疾病 (DJD) 包括诸如骨关节炎和脊柱退化等疾病.
- 痴呆症,包括阿尔茨海默氏症和血管痴呆症,构成了重大的公共卫生挑战.
- DJD与痴呆风险之间的关系以及潜在的生物机制需要进一步研究.
研究的目的:
- 调查DJD与发展痴呆症的风险之间的关联.
- 确定可能解释DJD与痴呆症之间的联系的蛋白质介质.
- 基于这些机制,探索潜在的痴呆症预防治疗点.
主要方法:
- 对500,805名英国生物库参与者进行了前性队列研究.
- 追踪DJD诊断和痴呆症结果的中位数为14.45年.
- 用多变量考克斯回归,倾向性得分匹配和血蛋白质组分析来分析关联并识别介质.
主要成果:
- DJD与所有原因痴呆症 (ACD) 和血管痴呆症 (VaD) 的风险显著增加有关,但不是阿尔茨海默病 (AD).
- 蛋白质组分析确定了18种血蛋白,包括HAVCR1,GDF15和COL6A3,这些蛋白质显著调解了DJD和ACD之间的关联.
- 根据年龄,活动水平和手术史观察到效果的修改.
结论:
- 退行性关节疾病独立地与更高的痴呆风险有关.
- 涉及HAVCR1,GDF15和COL6A3等蛋白质的系统性蛋白质基因变化调解了这种关联.
- 炎症和血管功能障碍被强调为中心机制,为痴呆风险分层和治疗干预提供了潜在的途径.
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