逆侧脑区域在慢性ICA闭塞患者的脑动态功能连接中表现出半球差异
Zhongyan Wang1,2,3, Yuetong Liu4, Haiyan Qian5
1From the Department of Radiology (Z.W., M.S.), Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
AJNR. American journal of neuroradiology
|December 30, 2025
概括
动态功能连接在内动脉 (ICA) 堵塞的患者的逆侧大脑中不同. 休息状态的fMRI显示出基于慢性ICA封闭的一侧明显的网络变化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 动脉狭窄病影响大脑结构和功能.
- 之前的研究主要关注体积缩和结构损伤.
- 慢性内动脉 (ICA) 阻塞中的动态功能连接 (FC) 需要进一步调查.
研究的目的:
- 在患有慢性ICA闭塞的患者中调查逆侧大脑动态功能连接.
- 将右侧和左侧ICA阻塞之间的FC差异进行比较.
- 使用静止状态fMRI进行动态FC分析.
主要方法:
- 招募了患有慢性右ICA闭塞 (n=21) 和左ICA闭塞 (n=11) 的患者.
- 包括一个健康个体的对照组 (n=16).
- 采用静态fMRI,集群分析和动态图形理论,使用滑动窗口方法.
主要成果:
- 右 ICA 阻塞影响了运动传感和前置默认网络.
- 左侧ICA闭塞影响了后部默认,突出和正面-状网络.
- 受影响的地区主要位于主导半球.
结论:
- 在患有慢性ICA封闭症的患者中,逆侧脑动态FC存在显著变化.
- 闭塞的一面影响受影响的特定大脑网络.
- 动态图形理论有效地揭示了这些半球差异.
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