更新的全瘤指南用于病理反应的新辅助评分:SITC和INMC的联合努力
J S Deutsch1, R A Scolyer2, E Burton3
1Departments of Dermatology, Pathology, and Oncology, and The Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University SOM, Baltimore, USA.
概括
标准化的病理反应评估对于新辅助性癌症治疗至关重要. 这种全瘤方法协调了评分和报告,改善了临床试验数据和患者结果分层.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 临床试验 临床试验
背景情况:
- 新辅助疗法是高风险切除癌症的关键策略.
- 以前的病理反应评估缺乏跨瘤类型的标准化.
- 对于病理反应评估和数据采集的协调准则的需求至关重要.
研究的目的:
- 在新辅助癌症治疗中更新和标准化病理反应评估指南.
- 协调不同癌症类型的数据采集和报告.
- 建立一个统一的系统来评估治疗疗效.
主要方法:
- 召集了来自PATHdata和INMC的病理学,瘤学和外科手术专家.
- 制定了关于样本处理,组织提交,评分和报告的共识指南.
- 基于与患者结局相关的组织学特征的更新建议,考虑全瘤共同点和特点.
主要成果:
- 推的标准化瘤总输送量为≤3厘米的样本.
- 使用剩余可活瘤百分比 (%RVT),缩和回归的量化病理反应.
- 提供了标准化的报告模板,并确定了用于验证的关键数据点.
结论:
- 病理反应评估的标准化至关重要,因为它成为了替代终点.
- 全瘤方法促进了结果分层和跨试验和瘤类型的比较.
- 该框架支持数据收集,并确定适应辅助治疗的临床上有意义的RVT切断点.
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