蒸发大麻与安慰剂治疗急性偏头痛:一个随机,双盲,安慰剂控制的交叉试验
Nathaniel M Schuster1,2, Mark S Wallace1,2, Thomas D Marcotte2,3
1Center for Pain Management, Department of Anesthesiology, University of California San Diego Health System, La Jolla, California, USA.
Headache
|December 30, 2025
概括
大麻中的THC和CBD的组合有效地治疗急性偏头痛,在2小时内提供缓解,持续效益长达48小时. 这种大麻素治疗在一项随机临床试验中显示出优于安慰剂的优势.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 大麻素科学 大麻素科学
背景情况:
- 临床前和回顾性研究表明,大麻素对偏头痛的潜在疗效.
- 之前没有任何随机临床试验研究了大麻素用于急性偏头痛治疗.
研究的目的:
- 评估含有特定比例THC和CBD的蒸发大麻在急性偏头痛缓解中的有效性.
- 为了比较THC主导,CBD主导,THC+CBD组合和安慰剂大麻对偏头痛症状的影响.
主要方法:
- 随机,双盲,安慰剂控制,交叉试验,涉及92名头痛成年人.
- 参与者用蒸发的6%THC,11%CBD,6%THC+11%CBD或安慰剂治疗了多达四次偏头痛发作.
- 主要终点是蒸发后2小时的疼痛缓解;次要终点包括疼痛自由和最烦人的症状自由.
主要成果:
- 6%的THC+11%的CBD组合在2小时后在缓解疼痛方面表现出优于安慰剂的优势 (67.2%对46.6%),无疼痛 (34.5%对15.5%) 和最烦人的症状自由 (60.3%对34.5%).
- 在2小时内,THC主导的大麻在缓解疼痛方面优于安慰剂,但在其他终点方面没有优势.
- 与安慰剂相比,CBD主导的大麻没有显著差异.
- 持续的疼痛自由和最烦人的症状自由在THC+CBD组合下观察到长达48小时.
结论:
- 含有6%THC+11%CBD的蒸发大麻是急性偏头痛的有效治疗方法.
- 这种大麻素组合可以为偏头痛患者提供快速的疼痛缓解和持续的症状释放.
- 在试验期间没有报告任何严重不良事件.
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