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Updated: Jan 7, 2026

Time-lapse Microscopy of Early Embryogenesis in Caenorhabditis elegans
07:58

Time-lapse Microscopy of Early Embryogenesis in Caenorhabditis elegans

Published on: August 25, 2011

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在胚胎发生过程中寄生性线虫的染色质可访问性景观

Hanyu Lu1, Tulio Campos1,2, Sunita B Sumanam1

  • 1Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, Victoria, 3010, Australia.

BMC genomics
|December 30, 2025
PubMed
概括

这项研究绘制了Haemonchus contortus中的染色质可访问性,揭示了参与发育和基本功能的关键调节基因. 这项工作为了解寄生性线虫生物和宿主相互作用提供了基础.

关键词:
海蒙丘斯 (Haemonchus contortus) 是一个长长的鱼类.ATAC-seqq 的使用情况.染色体的可访问性 染色体的可访问性胚胎发生是胚胎发生.基因调节 基因调节寄生虫线虫是一种寄生虫线虫.

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Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq10:23

Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
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Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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