和多醇基物质 (PFAS) 暴露和心血管风险:脂质特征作为介质
Xianghai Wang1, Yongping Cao2, Xuli Chen3
1Department of Cardiology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, China.
暴露于per-和多醇基物质 (PFAS) 可能会影响心血管疾病 (CVD) 风险和脂质配置文件. 特定的PFAS及其混合物与心血管疾病有关,而胆固醇则调解这些影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
背景情况:
- 和多基物质 (PFAS) 暴露与心血管疾病 (CVD) 之间的关系尚不清楚,尤其是在长链PFAS逐步淘汰期间.
- 了解脂质配置文件在PFAS相关心血管疾病中的作用对于公共卫生至关重要.
研究的目的:
- 调查个人PFAS与心血管疾病风险和脂质代谢之间的关联.
- 评估PFAS混合物对心脏病风险的综合影响.
- 探索脂质资料在PFAS-CVD关系中的调解作用.
主要方法:
- 分析了来自25531名NHANES参与者的数据 (2015-2020年).
- 对于单个PFAS协会的物流和多变量线性回归.
- 贝叶斯核机器回归,加权量子位和量子位g计算用于混合物分析.
- 评估脂质中间体的因果调解模型.
主要成果:
- 特定的PFAS (PFNA,n-PFOA,n-PFOS,Sm-PFOS) 与心血管疾病风险相反相关.
- 暴露于PFAS与改变的总胆固醇,甘油三,LDL和HDL水平有关.
- PFAS混合物显示出与心血管疾病风险的逆趋势,Sm-PFOS是主要的贡献者.
- 总胆固醇和LDL胆固醇调解了某些PFAS和心血管疾病之间的关系.
结论:
- 当代的PFAS暴露档案可能通过脂质通路对心血管健康产生差异性影响.
- 持续监测和机制研究对于PFAS风险评估和监管至关重要.
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