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在右侧结肠癌中加速表观遗传年龄预测了有利的结果

Qin Ye¹, Ping Song¹, Wangxiong Hu²

¹Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.

Clinical epigenetics

|December 30, 2025

概括

表观遗传加快年龄 (EAA) 在右侧和左侧结直肠癌 (CRC) 之间有所不同. EAA是CRC预后和向治疗的潜在生物标志物,提供了CRC异质性的见解.

科学领域:

表观遗传学和衰老研究研究.
癌症生物学和基因组学
瘤学和临床研究.

背景情况:

DNA甲基化年龄 (epiAge) 是一个已验证的衰老和癌症的生物标志物.
大肠直肠癌 (CRC) 是异质的,按瘤位置分类:左侧 (LCC),右侧 (RCC) 和直肠.
需要澄清表观遗传衰老加速 (EAA) 和CRC特征/结果之间的关系.

研究的目的:

调查EAA与CRC瘤位置 (LCC与RCC) 的关联.
探索EAA与CRC的临床特征和患者存活率的相关性.
评估EAA作为CRC异质性和预后的潜在生物标志物.

主要方法:

在548个CRC样本上使用四种模型 (Horvath2013,PhenoAge,ZhangQ2019,EpiTOC) 估计EpiAge (96个结对瘤/正常,356个TCGA瘤).
在LCC和RCC之间比较EpiAge和EAA.
记录等级测试来评估EAA与LCC和RCC存活率的关联.

主要成果:

与LCC相比,在RCC中观察到显著更高的epiAge (P=0.00025).
在女性和微卫星不稳定性高的RCC中EAA升高,并在RCC和LCC中显示出明显的特定阶段模式.
EAA证明了与RCC死亡率的显著负相关性和与LCC死亡率的积极相关性.

结论:

从生物衰老的角度来看,EAA是理解CRC异质性的宝贵生物标志物.
EAA可以帮助预后判断,并指导针对CRC的向治疗策略.
这些发现突显了EAA在结直肠癌个性化瘤学的潜力.

关键词:

时间表年龄年代表年龄通过DNA甲基化.表观遗传年龄加速基因表观时钟是什么?右侧结肠癌是右侧结肠癌.

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