多变体胎儿生长轨迹建模及其与母体脂肪酸的关联
Shuai Huang1, Jia-Jia Tang2, He-Bin Chi2
1Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Scientific reports
|December 30, 2025
概括
孕产妇脂肪酸会影响胎儿的发育. 妊娠早期的酸 (LA) 和α-酸 (ALA) 含量与特定的胎儿生长轨迹和不良结果有关.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 围产期流行病学 围产期流行病学
背景情况:
- 母体循环中的脂肪酸对胎儿发育至关重要.
- 有限的研究存在于早期孕期的孕产妇脂肪酸和胎儿生长轨迹.
- 了解这些联系可以为最佳胎儿生长提供干预信息.
研究的目的:
- 为了研究11-14周孕期母亲血清脂肪酸水平与胎儿生长轨迹之间的关联.
- 为了确定与不同的胎儿生长模式相关的特定脂肪酸.
- 探索这些轨迹与不良妊娠结果之间的联系.
主要方法:
- 基于组的多轨迹建模 (GBMTM) 用于定义胎儿生长轨迹 (头周长,双面直径,腹周长,股骨长度z-scores).
- 在655名怀孕妇女的11-14周怀孕时,使用GC-MS量化了母亲血清脂肪酸.
- 多项逻辑回归和基于量子的g计算分析了脂肪酸和轨迹组之间的关联.
主要成果:
- 确定了四种不同的胎儿生长轨迹:稳定下降,稳定增长,高稳定增长和急剧下降.
- 较高的母体氨酸 (LA) 和α-氨酸 (ALA) 与稳定下降和急剧下降轨迹的几率增加有关.
- 乙酸 (EDA) 与稳定的下降轨迹的几率降低有关.
结论:
- 胎儿生长轨迹是可分类的,并与不良妊娠结果相关,如对妊娠年龄大和宏观性.
- 怀孕早期母亲血清中的LA,ALA和EDA水平与胎儿生长轨迹的表型有显著的关联.
- 这些发现凸显了孕早期母亲脂肪酸特征对胎儿发育的重要性.
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