PIC-SURE:一个开源平台,用于整合临床和基因组数据
Alba Gutiérrez-Sacristán1, Emily E Hughes1, Ryan Amari1
1Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA, USA.
NPJ digital medicine
|December 30, 2025
概括
PIC-SURE是一个开源平台,用于整合和分析大规模的临床和基因组数据. 它可以实时构建和分析超过140万名参与者的队列,支持可重复的研究.
科学领域:
- 生物信息学和计算生物学
- 基因组数据分析 基因组数据分析
- 临床数据整合技术
背景情况:
- 大规模的临床和基因组数据集对于生物医学研究至关重要,但存在整合和分析挑战.
- 现有的平台可能缺乏对各种数据类型的实时分析所需的灵活性和可扩展性.
- 国家卫生研究院 (NIH) 国家心脏,肺和血液研究所 (NHLBI) 生物数据催化剂®生态系统旨在促进数据共享和分析.
研究的目的:
- 推出PIC-SURE,一个开源平台,旨在无集成和分析大规模的临床和基因组数据.
- 突出PIC-SURE在实现实时队列构建和数据探索方面的能力.
- 展示PIC-SURE如何降低研究人员使用集成数据集进行可扩展和可重复研究的障碍.
主要方法:
- 使用开源平台架构,以实现广泛的可访问性和社区贡献.
- 实现图形用户界面 (GUI) 和应用程序编程界面 (API) 以实现多功能数据交互.
- 与NIH NHLBI BioData Catalyst®生态系统集成,以利用现有数据资源.
主要成果:
- PIC-SURE提供了来自273项研究的数据访问和分析能力,涵盖约140万参与者 (截至2025年5月).
- 该平台可实现复杂,综合的临床和基因组数据集的实时探索和分析.
- 证明了支持可扩展和可重复的研究工作流程的能力.
结论:
- PIC-SURE有效地解决了整合和分析大规模临床和基因组数据的挑战.
- 该平台通过实时队列构建和分析来提高研究效率和可重复性.
- 在NIH NHLBI生物数据催化剂®生态系统中,PIC-SURE作为一个有价值的工具,促进数据驱动的生物医学发现.
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