美国食品和药物管理局 (FDA) 批准的药物的低使用率用于成人状细胞疾病
Joshua G Rivenbark1, Alan C Kinlaw2, Justin G Trogdon3
1Division of Hematology, University of North Carolina at Chapel Hill, Durham, North Carolina, USA.
European journal of haematology
|December 31, 2025
概括
状细胞病 (SCD) 药物的处方率仍然很低,约25%的患者使用氨酸. 改善血液学家的准入可能会增加这些重要的SCD治疗的利用率.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 状细胞疾病 (SCD) 的治疗环境正在发展,但人口级别关于药物处方率的数据很少.
- 了解当前的处方模式对于优化患者护理和获得SCD治疗方法至关重要.
研究的目的:
- 分析北卡罗来纳州状细胞病 (SCD) FDA 批准的药物处方率.
- 确定与使用SCD特异性药物和阿片类止痛药相关的因素.
主要方法:
- 一个横截面,年化队列分析使用北卡罗来纳州医疗补助索赔数据从2018-2022.
- 使用行政数据算法识别了患有SCD的成年人,并计算了氧尿素,L-谷氨胺,voxelotor,crizanlizumab和阿片类药物的处方率.
- 两位式混合效应模型被用来检查药物处方和个体特征之间的关联.
主要成果:
- 在1733名个人中,每年Hydroxyurea处方率从24.2%到26.7%不等.
- 对于L-Glutamine,Voxelotor和Crizanlizumab的使用率每年都在6.0%以下.
- 片类止痛药处方率在51.4%至53.9%之间变化,而看血病学家与接受SCD特定药物的更高几率相关.
结论:
- 在受研究的人群中,FDA批准的状细胞疾病 (SCD) 药物的使用率显著较低.
- 年龄和性别等因素影响了处方模式,男性显示出更高的氧尿素几率.
- 加强对血液学家的接触,是改善SCD特异性疗法的潜在策略.
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