EASIX与缺血性中风患者的短期和长期预后之间的相关性
Jinchuang Li1, Zhouxin Wu1, Zhuoshi Yang1
1First School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.
BMC neurology
|December 31, 2025
概括
内皮激活和压力指数 (EASIX) 与缺血性中风 (IS) 患者的死亡率较高有关. 较高的EASIX分数表明风险增加,有助于患者分层和预后.
科学领域:
- 关键护理医学 关键护理医学
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 研究了内皮激活和压力指数 (EASIX) 与缺血性中风 (IS) 患者的死亡率之间的相关性.
- 使用MIMIC-IV 3.0数据库进行全面的患者数据分析.
研究的目的:
- 评估EASIX在预测IS患者短期 (30天) 和长期 (1年) 死亡率方面的预后价值.
- 为优化IS患者风险分层和临床管理策略提供见解.
主要方法:
- 包括来自MIMIC-IV 3.0数据库的3625名急性IS患者.
- 根据血小板计数,肌素和乳酸脱酶计算的log2-EASIX得分.
- 采用多变量考克斯模型,LASSO回归,卡普兰-梅尔曲线和受限立方斜线进行分析.
主要成果:
- 较高的EASIX四分位数与显著增加的30天和1年死亡率有关.
- 完全调整后的考克斯模型显示,EASIX最高四分位数 (Q4) 与最低四分位数 (Q1) 相比,死亡风险较高.
- 限制性立方线分析显示了EASIX与死亡率之间的非线性关联,预测值中等 (AUCs~0.73-0.75).
结论:
- 在ICU入院IS患者中,EASIX是短期和中期全因死亡率的独立预测器.
- 较高的EASIX水平与死亡率的增加相关,使其成为风险分层和预后的有价值工具.
- 需要进一步的前性研究来阐明EASIX在IS预后中的因果机制.
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