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卡尔-T细胞作为多发性硬化症和其他神经免疫疾病的新疗法

Sara Samadzadeh^1,2,3, Natalia Szejko^4,5,6,7, Yara Hamadah⁸

¹Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Berlin, 12203, Germany.

Journal of neuroinflammation

|December 31, 2025

概括

化学抗原受体 (CAR) T细胞疗法通过向自身反应性B细胞,对神经免疫性疾病具有前景. 这种方法可以提供持久的B细胞枯竭和免疫重编程,可能会将治疗从免疫抑制转向长期耐受性.

科学领域:

神经免疫学神经免疫学
细胞疗法细胞疗法
自免疫神经学自免疫神经学

背景情况:

像MS,NMOSD,MOGAD和MG这样的神经免疫疾病涉及自主反应性B细胞,导致慢性炎症和组织损伤.
目前的免疫疗法通常需要终身治疗,并与中枢神经系统炎症作斗争.
从癌症治疗中调整的CAR T细胞疗法,针对B细胞进行持久的枯竭和免疫重编程.

研究的目的:

审查目前关于神经炎症疾病中CAR T细胞治疗的证据.
探索CAR T细胞的潜力,将治疗模式转向免疫耐受性.
突出了对不同患者群体和疾病谱的进一步研究的需要.

主要方法:

临床前数据和早期临床试验结果的综合.
评估CD19和BCMA导向的CAR T细胞疗法的疗效和安全性.
对治疗多发性硬化症和其他罕见神经免疫疾病的CAR-T细胞疗法的研究综述.

主要成果:

卡尔T细胞疗法显示出在自身免疫性疾病中有针对性,持久的B细胞枯竭的潜力.
早期的研究表明,复发率降低,残疾稳定,自身抗体减少.
与瘤学用途相比,观察到较低的CRS和ICANS率的有利安全概况.

结论:

卡尔T细胞疗法代表了神经免疫性疾病的变革性治疗方法.
它提供了从慢性免疫抑制向长期免疫耐受性的潜在转变.
进一步的研究至关重要,以实现跨异质人群和疾病谱的全部治疗潜力.

关键词:

自免疫性疾病自免疫性疾病自免疫神经学自免疫神经学 B 细胞 B 细胞 B 细胞化学抗原受体t细胞的t细胞免疫治疗是一种免疫疗法.多发性硬化症是多发性硬化症.神经炎症是一种神经炎症.

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