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在医疗ICU患者中,MASLD与基线和新发性肝功能测试升高的关联

Ali Karataş¹, Kamil İnci², Nazlıhan Boyacı Dündar²

¹Department of Gastroenterology, Faculty of Medicine, Gazi University, Ankara 06560, Turkey.

Medicina (Kaunas, Lithuania)

|December 31, 2025

概括

代谢功能障碍相关的脂肪性肝病 (MASLD) 在ICU患者中很常见,显示肝酶高,对器官支持的需求增加. 然而,MASLD本身并不能独立预测严重疾病中的死亡率.

科学领域:

肝病学肝病学是一种肝病学.
关键护理医学关键护理医学
胃肠病学胃肠病学

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 很普遍,可能会影响严重疾病的结果.
异常肝功能测试 (LFTs) 在ICU中很常见,但MASLD在肝脏脆弱性和死亡率中的作用尚不清楚.

研究的目的:

评估先前存在的MASLD和LFT异常 (基线和新发病) 之间的关联.
评估MASLD对非肝硬化医疗ICU患者的ICU结果的影响.

主要方法:

追溯性队列研究,对609名成年非肝炎ICU患者进行了追溯性队列研究.
MASLD被定义为肝硬化症,具有≥1个心脏代谢风险因子.
在MASLD和非MASLD组之间比较基线和72小时LFT,损伤模式和ICU结果;为LFT升高和死亡率的预测因素进行后勤回归.

主要成果:

在39.4%的患者中诊断出MASLD.
在72小时后,MASLD患者更频繁的基线LFT升高 (由ALP驱动) 和更高的ALP/GGT.
MASLD患者需要更具侵入性的机械通风,CRRT,并且患病室感染率更高,但MASLD不是死亡率的独立预测因素.

结论:

在医疗ICU患者中,MASLD很常见,与胆固醇化生化特征和较差的ICU结果有关.
系统性严重程度和器官支持需求,而不是MASLD本身,主要决定早期肝损伤和ICU死亡率.

关键词:

重症监护病房的重症监护病房是一个重症监护病房.肝功能测试肝功能测试肝功能测试与代谢功能障碍相关的脂肪性肝病.

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