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普兰托西亚尼丁对HGF-1和HPDLF细胞的增殖作用:一个体外研究

Evelina Alkimavičienė¹, Nomeda Basevičienė¹, Arvydas Strazdauskas²

¹Department of Dental and Oral Pathology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.

Medicina (Kaunas, Lithuania)

|December 31, 2025

概括

佩拉戈尼乌姆赛多伊德根提取物 (PSRE) 促进牙周组织细胞增殖,与赫西丁二甲酸盐 (CHX) 不同,该药物表现出细胞毒性作用. 在较低度下,PSRE可以在牙周治疗中增强愈合,而不会产生负面影响.

科学领域:

牙周病学牙周病学
细胞生物学细胞生物学
药理学药理学是指药理学的学科.

背景情况:

当与标准治疗一起使用时,普兰托西亚尼丁 (PACNs) 可能会改善牙周和周围植入物组织的愈合.
赫西丁二甲酸盐 (CHX) 是治疗牙周病的标准治疗方法.
目前正在研究Pelargonium sidoides根提取物 (PSRE) 的治疗潜力.

研究的目的:

评估不同度的Pelargonium sidoides根提取物 (PSRE) 对牙周组织纤维细胞增殖的影响.
为了比较PSRE与赫西丁二甲酸盐 (CHX) 的作用.

主要方法:

使用了人类牙纤维细胞 (HGF-1) 和人类牙周带纤维细胞 (HPDLF) 细胞系.
细胞暴露于不同度的CHX和PSRE.
测量了细胞活力,增殖 (PrestoBlue测定) 和TGFβ-1水平 (ELISA).

主要成果:

与对照组相比,25μg/mL的PSRE显著增加了HGF-1细胞生长 (p=0.006).
在HGF-1细胞上,CHX表现出最强的细胞毒性作用 (p < 0.001).
PSRE (25和50微克/毫升) 在HGF-1和HPDLF细胞中显著增加了TGFβ-1水平 (p < 0.001),在100微克/毫升以下没有不良影响.

结论:

可能来自PSRE的PACN可能会促进HGF-1和HPDLF细胞的增殖.
PSRE显示出作为治疗性剂的潜力,用于牙周组织的愈合.
CHX显示了细胞毒性作用,突出显示了标准牙周治疗的潜在局限性.

关键词:

氧化的含量是多少纤维细胞的细胞.在体外 (in vitro) 技术牙周炎是指牙周炎的一种疾病.氨基氨基酸是什么? 氨基酸是什么

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