罗马尼亚重症监护病房的抗性动态:ESKAPE病原体监测四年
Mihai Sava1,2, Ioana Roxana Codru1,2, Alina Simona Bereanu1,2
1County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania.
Medicina (Kaunas, Lithuania)
|December 31, 2025
概括
来自ESKAPE病原体的抗菌素耐药性是罗马尼亚ICU的主要威胁. 克莱布西拉肺炎和Acinetobacter baumannii表现出高度的多药性和广泛的耐药性,随着时间的推移而增加.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球严重的健康威胁,特别是在重症监护病房 (ICU).
- 逃生病原体 (菌杆菌,黄金葡萄球菌,肺炎菌,宝曼菌, Pseudomonas aeruginosa, Enterobacter spp.) 没有被发现. 是医疗保健相关感染的主要原因.
- 罗马尼亚面临着高消费率和抗微生物药物耐药性,需要进行本地流行病学研究.
研究的目的:
- 分析罗马尼亚ICU中ESKAPE病原体的流行病学趋势.
- 在四年 (2021-2024) 期间,对这些分离物的抗微生物耐药性概况进行表征.
主要方法:
- 来自成年ICU患者的微生物样本的回顾性观察性研究.
- 从2021-2024年在西比乌临床急救县医院收集的数据.
- 分析包括患者人口统计,样本类型,孤立的微生物和使用统计方法的耐药性分类.
主要成果:
- 在801例记录的感染中,ESKAPE病原体占70.2%.
- 克莱布西拉肺炎 (42.8%) 和Acinetobacter baumannii (36.0%) 是ESKAPE的主要生物体.
- 近一半 (47.3%) 的分离物是多药耐药的,22.3%是广泛耐药的,观察到显著的时间增加.
结论:
- 逃生病原体是罗马尼亚ICU感染的主要驱动因素.
- 多种药物和广泛耐药的Klebsiella肺炎和Acinetobacter baumannii感染的高发病率是一个主要问题.
- 加强感染预防,抗菌药物管理和监测对于打击罗马尼亚ICU中日益增长的耐药性至关重要.
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