血清kynurenine通路代谢物作为垂体腺瘤的候选诊断生物标志物:一个病例对照研究
Nur Düzen Oflas1, Halil İbrahim Akbay2, Murat Alay3
1Department of Internal Medicine, Faculty of Medicine, University of Van Yuzuncu Yil, 65090 Van, Türkiye.
Medicina (Kaunas, Lithuania)
|December 31, 2025
概括
来自金氨酸路径的关键代谢物和酶,包括金氨转移酶 (KAT) 和金酸 (KYNA),显示出作为垂体腺瘤的非侵入性生物标志物的潜力. 这些物质的高水平可以帮助区分患者和健康个体.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
背景情况:
- 垂体腺瘤是常见的内瘤.
- 目前,缺少用于垂体腺瘤的特定非侵入性生物标志物.
研究的目的:
- 调查金氨酸途径代谢物和酶作为垂体腺瘤诊断生物标志物的潜力.
- 使用这些生物标志物,区分患有垂体腺瘤的患者与健康对照者.
主要方法:
- 一项病例对照研究,涉及50名垂体腺瘤患者和35名健康对照.
- 使用ELISA测量了氨酸2,3-二氧化酶 (IDO),氨酸 (KYN),氨酸 (KYNA),氨酸转移酶 (KAT),氨酸和氨酸的血清水平.
- 统计分析包括ROC曲线分析和多变量后勤回归.
主要成果:
- 在垂体腺瘤患者中,KYN,KYNA,皮科林酸,IDO和kynureninase的血清水平显著升高 (p < 0.001).
- 基氨基转移酶 (KAT) 和KYNA的诊断准确性非常好 (AUC分别为0.923和0.901).
- IDO,KYN和KYNA被确定为垂体腺瘤的独立预测因子.
结论:
- kynurenine 途径代谢物和酶显示出作为 pituitary 腺瘤的非侵入性生物标志物的显著潜力.
- 升高的KAT和KYNA水平为垂体腺瘤检测提供了高的诊断性能.
- 一个基努瑞宁途径代谢物的小组可以促进早期的,非侵入性下垂体腺瘤的诊断.
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