心脂肪组织升高和缺血性中风风险:系统性审查和元分析
Arankesh Mahadevan1, Monitha Pinnamaneni2, Manaswini Krishnakumar3
1Department of Neurology, University of Utah Health, Salt Lake City, UT 84132, USA.
Medicina (Kaunas, Lithuania)
|December 31, 2025
概括
心上脂肪组织 (EAT) 的增加与急性缺血性中风 (AIS) 的更高风险有关,特别是在患有心血管疾病如心房动 (AFib) 的患者中. 测量EAT可能有助于预测中风风险.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心脂肪组织 (EAT) 是一种具有促炎性质的内脏脂肪库.
- 吃有助于心血管疾病,包括心房动 (AFib) 和急性缺血性中风 (AIS).
- 在患有并发症的患者中,EAT和AIS风险之间的关联需要进一步调查.
研究的目的:
- 进行一项元分析,评估心表脂肪组织 (EAT) 与急性缺血性中风 (AIS) 风险之间的关联.
- 专注于现有心血管并发症的人群,如AFib.
- 探索EAT在中风病理生理学中的作用.
主要方法:
- 遵守MOOSE和PRISMA指导方针进行元分析.
- 在PubMed,SCOPUS和Embase数据库中进行全面的文献搜索.
- 包括RCT,队列,病例控制和横截面研究与统计分析,使用聚合几率比率 (OR) 和随机效应模型.
主要成果:
- 包括8项涉及7412名参与者的研究.
- 增加的EAT厚度与AIS更高的几率显著相关 (aOR:3.60 [2.26-5.74]).
- 较高的上心脂肪体积也与增加的AIS风险有关 (aOR: 1.17 [1.03-1.34]).
结论:
- 增加EAT厚度和体积与心血管并发症患者的AIS风险增加有关.
- EAT的炎症性和促血栓性特征可能在中风的发展中发挥作用.
- 在临床实践中,EAT评估可以提高中风风险分层.
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