局部麻醉剂对实验术后粘附的影响:系统性审查和元分析与试验序列分析
Joon-Hee Lee1, Donghyun Lee1, Hyun Kang2
1Department of Integrative Engineering, Chung-Ang University Graduate School, Seoul 06974, Republic of Korea.
Medicina (Kaunas, Lithuania)
|December 31, 2025
概括
局部麻醉剂 (LA) 可能会减少术后粘附,但证据有限. 由于目前动物研究的确定性低,样本大小不足,需要进一步研究.
科学领域:
- 手术研究的研究.
- 麻醉学 麻醉学
- 生物材料科学是生物材料的科学.
背景情况:
- 手术后的粘附是手术后的严重并发症.
- 局部麻醉剂 (LA) 通常用于手术后的疼痛管理.
- 需要对LA的潜在抗粘性质进行调查.
研究的目的:
- 系统地审查和元分析关于局部麻醉剂 (LA) 抗粘性作用的动物研究.
- 使用适应GRADE的框架和试验顺序分析 (TSA) 来评估证据的确定性.
主要方法:
- 在多个数据库 (Ovid-MEDLINE,EMBASE,Web of Science,Google Scholar) 中进行了全面的文献搜索.
- 包括的研究是动物模型,研究LA对术后粘附的影响.
- 结果包括宏观 (粘附评分) 和显微 (炎症,纤维化) 评估.
主要成果:
- LA与减少的总宏观粘附得分 (SMD-1,528) 和改善的粘附质量有关.
- 此外,LA还显示出降低微观粘附严重程度 (SMD-1.304) 和纤维化 (SMD-2.373) 的潜力.
- 试验的顺序分析表明,样本大小不足以得出坚定的结论,证据的确定性低至非常低.
结论:
- 局部麻醉剂可能具有预防性作用,防止术后粘附形成.
- 然而,目前的证据的确定性低至非常低.
- 样本规模不足和包含的研究中偏差的高风险限制了最终的结论.
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