尿路微生物组合在治疗前的膀癌:一个病例对照研究与瘤侵入性分层
Ahmet Kayer1, Ata Özen1, Ener Çağrı Dinleyici2
1Department of Urology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir 26040, Türkiye.
Medicina (Kaunas, Lithuania)
|December 31, 2025
概括
膀癌患者和健康个体之间的尿道微生物群不同,在癌症病例中丰富的特定细菌如Enterococcus. 需要进一步的研究来证实这些膀癌微生物组发现.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 新出现的证据将生殖尿道微生物群与泌尿病恶性瘤联系起来.
- 尿道微生物组在膀癌的发展和进展中的作用正在研究中.
研究的目的:
- 在诊断时诊断出膀癌患者的尿道微生物群的特征.
- 为了比较膀癌患者和健康对照者的尿道微生物群组成.
- 研究肌肉侵入性膀癌 (MIBC) 和非肌肉侵入性膀癌 (NMIBC) 之间的差异.
主要方法:
- 16S rRNA测序用于分析30名膀癌患者和20名健康对照者的尿样.
- 对MIBC和NMIBC进行了子组分析.
- 线性差异分析效果大小 (LEfSe) 确定了差异丰富的种类.
主要成果:
- 两组之间没有观察到α或β多样性的显著差异.
- 在膀癌患者中,固形菌相对较为丰富.
- 在膀癌患者中,特别是MIBC中,Enterococcus是最丰富的属性,而Lactobacillus在对照中更为普遍.
- 在MIBC中丰富了Veillonella dispar. 在MIBC中丰富了Veillonella dispar.
- LEfSe在膀癌患者或对照人群中确定了特定的细菌种群,这些细菌种群富含.
结论:
- 尿路微生物群的初步差异与膀癌和瘤侵入性有关.
- 这些发现表明,尿路微生物组在膀癌中可能发挥作用.
- 需要进行更大规模的研究来证实这些探索性发现并评估它们的临床相关性.
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