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在术后代谢和腹部外科手术中还原反应:对心血管风险标志物的新见解
Ruanda Pereira Maia1, Sandra Fernandes Arruda1, Ariene Silva do Carmo1,2
1Graduate Program in Human Nutrition, Department of Nutrition, Faculty of Health Science, University of Brasília, Brasília 70910-900, Brazil.
Nutrients
|December 31, 2025
概括
代谢和减肥手术 (MBS) 与心血管益处有关,但对氧化还原反应和心脏健康标志物的长期影响尚不清楚. 氧化损伤,而不是抗氧化活性,与MBS多年后扩张性血压和脂质概况的增加有关.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 手术研究的研究.
背景情况:
- 代谢和减肥手术 (MBS) 改善心血管风险因素,促进体重减轻.
- MBS对氧化还原反应和心血管风险标志物的长期影响需要进一步研究.
- 这项研究评估了氧化还原状态和心血管风险标志物MBS后几年的关系.
研究的目的:
- 评估在2-7年前接受MBS的患者中氧化还原反应标志物和心血管风险指标之间的关联.
- 为了确定长期的氧化损伤或抗氧化活性是否与MBS后的心血管健康指标相关.
主要方法:
- 分析了一组91名患者,这些患者在2至7年前接受了MBS.
- 量化了抗氧化酶活性和氧化损伤标记 (甲,碳化蛋白).
- 评估心血管风险标志物,包括血压,葡萄糖,脂质和甘油三/葡萄糖 (TyG) 指数,使用主要成分分析和通用线性模型.
主要成果:
- 确定了两个主要成分:酶的抗氧化活性和氧化损伤.
- 在酶性抗氧化活性和心血管风险标志物之间没有发现显著的关联.
- 氧化损伤标志物与透气血压,TyG指数,总胆固醇,甘油三 (TG) 和非HDL-C具有积极关联.
结论:
- 氧化损伤标志物与关键心血管风险因素有积极的关联,包括透气血压,TyG指数,TG,总胆固醇和非HDL-C,MBS多年后.
- 虽然MBS最初显示出好处,但持续的氧化压力可能会导致剩余的心血管风险.
- 需要进一步的研究来证实这些关联,并了解潜在的机制.
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