耶巴马特 (Ilex paraguariensis) 和类风湿性关节炎:机械和临床证据的系统审查
Manuela Cassotta1,2, Qingwei Cao3,4, Haixia Hu3,4
1Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, 39011 Santander, Spain.
Nutrients
|December 31, 2025
概括
耶巴马特及其化合物显示出对类风湿性关节炎 (RA) 有潜在的抗炎和抗氧化功效. 然而,需要更严格的临床试验来确认RA患者的这些影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特点是炎症和氧化应激.
- 伊莱克斯帕拉瓜里尼斯 (yerba mate) 含有生物活性化合物,如基酸,奎尔和鲁丁,它们以抗氧化和抗炎性质而闻名.
研究的目的:
- 系统地审查有关Ilex paraguariensis及其成分与RA特异性炎症,氧化和骨代谢途径相关的证据.
- 评估在类风湿性关节炎的背景下对yerba mate的机械和临床数据.
主要方法:
- 在2025年9月之前对PubMed/MEDLINE,LILACS和SciELO进行系统的文献搜索,遵守PRISMA 2020指南.
- 纳入关于yerba mate制剂 (过去10年) 或孤立化合物 (过去5年) 的研究,调查RA相关结果.
- 通过使用多种工具 (RoB 2,ROBINS-I,OHAT,SYRCLE) 对由于异质性和偏差评估风险的发现进行叙述综合.
主要成果:
- 23项研究 (11人,7实验室,5动物) 符合标准.
- 耶巴马特干预措施表明,炎症标志物 (例如CRP,IL-6) 的减少以及氧化平衡的改善.
- 在临床前模型中,像奎尔丁和鲁丁这样的单独化合物表现出类似的抗炎和抗氧化作用.
结论:
- 耶巴马特及其成分表现出与RA病理生理学相关的初步抗炎和抗氧化作用.
- 目前的证据是暂定的,因为缺乏RA特定的临床试验,样本规模小,方法异质.
- 未来的研究需要精心设计的随机对照试验和先进的人类相关的机制研究.
相关概念视频
Rheumatic Heart Disease III: Medical Management
263
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
263
Inflammatory Bowel Disease IV: Pharmacological Management
439
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
439
Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
439
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
439
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
454
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
454
Rheumatic Heart Disease I: Introduction
404
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
404


