摄入量和死亡风险:来自全国代表的韩国队列的证据
Jung-Hwan Cho1, Jun Young Kim2, Nak Gyeong Ko3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, Republic of Korea.
Nutrients
|December 31, 2025
概括
这项研究发现,高摄入量与韩国成年人死亡率之间没有联系. 需要进一步的研究来了解如何影响不同人群的健康.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 摄入对于甲状腺和代谢健康至关重要,影响公众健康.
- 关于摄入量和死亡率的纵向数据有限,特别是在非西方人群中.
- 亚洲人群具有较高的摄入量,因此需要研究敏感性的种族/区域差异.
研究的目的:
- 研究亚洲人口中摄入量与全因,心血管和癌症死亡率之间的关联.
- 为了解决西方国家以外有关摄入量和死亡率的纵向数据的稀缺性.
- 探索敏感性及其健康结果的潜在种族或区域差异.
主要方法:
- 从韩国国家健康和营养检查调查 (2013-2015) 中分析了5497名韩国成年人,并对死亡率进行了随访.
- 使用感应合血质谱法量化尿度 (UIC).
- 从UIC中估计摄入量,根据要求和上限分类,使用Cox比例危险模型进行分析.
主要成果:
- 在8.4年的时间里,过多的摄入量 (超过可容忍的上限) 与所有原因,心血管或癌症死亡率没有关联.
- 在不同类别的摄入量中没有观察到显著的死亡趋势.
- 敏感性和子组分析,包括排除患有甲状腺疾病的参与者,并没有改变主要发现.
结论:
- 这是第一个基于人口的亚洲研究,将摄入与死亡率联系起来,没有发现任何关联.
- 结果表明,与死亡率的关系在不同的全球人口中可能有很大差异.
- 进一步的大规模国际研究对于阐明暴露和死亡率之间的复杂相互作用至关重要.
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