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儿科MASLD的早期生活营养决定因素
1Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Nutrients
|December 31, 2025
概括
儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 具有独特的起源,从子宫开始. 早期的营养和母亲的健康显著影响后代的肝脏脂肪,突出了关键的干预窗口.
科学领域:
- 肝病学和代谢障碍 肝病和代谢障碍
- 儿科胃肠病学 儿科胃肠病学
- 发育营养 发展营养
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种广泛的肝病,影响儿童和成人.
- 儿科MASLD与成人形式相比呈现出明显的特征,这表明了独特的发育途径.
- 宫内和生命早期的因素越来越被认为在儿科MASLD的发病过程中至关重要.
研究的目的:
- 审查和综合有关与儿科MASLD相关的产前,产后和幼儿时代营养暴露的证据.
- 强调早期生命的关键窗口,以对抗儿科MASLD的潜在干预措施.
- 了解多重命中连续性,从子宫内促进MASLD的发展.
主要方法:
- 现有人类队列研究和机械模型系统的叙述性审查.
- 对营养暴露和肝脏脂质积累的收证据的综合.
- 专注于产前 (母亲的健康,饮食),产后 (养习惯) 和幼儿时期 (饮食质量) 的因素.
主要成果:
- 肥胖和妊娠期糖尿病等孕产妇因素与后代肝硬化症的增加有关.
- 产后养 (母乳养与添加糖的配方) 和幼儿饮食影响MASLD易感性.
- 遗传和环境因素的结合有助于儿科MASLD的异质性.
结论:
- 儿科MASLD发育是一个复杂的连续,受到早期暴露的影响.
- 怀孕和幼儿时期的营养干预对于预防MASLD至关重要.
- 针对生命早期的窗口提供了一个有希望的策略,以减少儿科MASLD的全球负担.
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