补充牛奶蛋白对人体组成和人体参数的影响:系统性审查和剂量反应元分析
Shooka Mohammadi1, Damoon Ashtary-Larky2, Navid Alaghemand2
1Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Nutrients
|December 31, 2025
概括
牛奶蛋白补充剂通过增加瘦身质量和无脂肪质量显著改善身体组成. 它还可以降低身体脂肪百分比,脂肪质量和腰围,支持有针对性的身体成分管理.
科学领域:
- 营养科学 营养科学
- 运动医学 运动医学
- 人体生理学 人体生理学
背景情况:
- 缺乏关于补充牛奶蛋白 (MP) 对身体组成 (BC) 的影响的共识.
- 在BC参数上需要对MP,蛋白 (CP) 和乳清蛋白 (WP) 进行全面分析.
- 随机对照试验 (RCT) 提供了多样化的证据.
研究的目的:
- 系统地审查和对MP补充和BC的RCT进行元分析.
- 评估MP摄入量和BC变化之间的剂量反应关系.
- 评估对人体参数的影响,例如瘦体质量 (LBM) 和脂肪质量 (FM).
主要方法:
- 到2025年10月,对RCT进行系统的文献搜索.
- 随机效应元分析,以汇总MP补充剂的效应.
- 剂量反应分析,以探索摄入量与效果的关系.
主要成果:
- 补充MP显著增加了LBM (0.41公斤) 和无脂肪质量 (FFM) (0.67公斤).
- 观察到身体脂肪百分比 (BFP) (-0.66%),脂肪质量 (FM) (-0.66公斤) 和腰围 (WC) (-0.69厘米) 的显著减少.
- 对肌肉质量 (MM),体重指数 (BMI) 或体重 (BW) 没有显著影响. 剂量反应分析显示,MP剂量影响了BFP,LBM和MM.
结论:
- 补充牛奶蛋白质会导致有利的身体成分变化.
- 增加了LBM和FFM,减少了FM,BFP和WC.
- 提供了MP在人体组成管理中的作用的一致证据.
相关概念视频
Overview of Protein Metabolism
3.5K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
3.5K
Proteins: Dietary Sources and Requirements
1.3K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.3K
Dose-Response Relationship: Overview
4.7K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.7K
Dose-Response Relationship: Potency and Efficacy
6.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.3K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
218
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
218
Drug Dosing: Obese Patients
195
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
195


