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在1型糖尿病-观察协会研究中的CTLA-4,FOXO-3和PTPN-22变体和环境因素之间的相互作用

Edyta Cichocka¹, Anna Maj-Podsiadło¹, Sylwia Barbara Górczyńska-Kosiorz¹

¹Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.

|December 31, 2025

概括

免疫基因CTLA-4和FOXO-3中的遗传变异影响1型糖尿病 (T1DM) 的自身免疫甲状腺疾病风险. 这些基因也可能影响T1DM患者的代谢健康和对维生素D和益生菌的反应.

科学领域:

免疫遗传学免疫遗传学
代谢障碍代谢障碍代谢障碍
环境健康环境健康

背景情况:

免疫调节基因 (CTLA-4,FOXO-3,PTPN-22) 影响免疫耐受性和新陈代谢.
这些基因与1型糖尿病 (T1DM) 的环境因素的相互作用尚不清楚.

研究的目的:

研究CTLA-4,FOXO-3和PTPN-22多态与T1DM的关联.
探索这些遗传变异如何与饮食,维生素D和益生菌使用等环境因素相互作用.

主要方法:

对277名患有T1DM的成年人进行了观察性研究.
对CTLA-4 (rs3087243,rs231775),FOXO-3 (rs2802292,rs9400239) 和PTPN-22 (rs12730735) 多态的基因定型.
评估与自身免疫性甲状腺疾病 (AITD),与代谢功能障碍相关的脂肪性肝病 (MASLD),饮食和补充剂使用的关联.

主要成果:

CTLA-4 rs3087243 G和FOXO-3 rs2802292 T等位基因与更高的AITD风险相关,具有性别特异性的影响.
携带CTLA-4G和FOXO-3T等位基因的携带者表现出代谢益处 (素食饮食,降低HbA1c).
FOXO-3 rs9400239 T与MASLD相关;维生素D显示出保护性趋势,而益生菌与特定基因型的AITD风险增加有关.

结论:

CTLA-4,FOXO-3和PTPN-22变种可能会影响T1DM的自身免疫和代谢反应.
这些遗传因素与环境暴露相互作用,包括营养素和补充剂.
了解这些相互作用对于管理T1DM并发症至关重要.

关键词:

美国国际援助署 (AITD)马斯尔德马斯尔德是什么意思维生素D 维生素D是一种维生素.饮食饮食饮食饮食环境因素环境因素遗传因素遗传因素代谢适应代谢适应益生菌益生菌是一种益生菌.第1类糖尿病 1型糖尿病

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