间歇性低巴性缺氧下工作人员的身体组成,微生物组和身体活动
Jorge Torres-Mejías1,2, Karem Arriaza3, Francisco Mena2
1Doctoral Program in Physical Activity Sciences, Faculty of Education Sciences, Universidad Católica del Maule, Talca 3530000, Chile.
Nutrients
|December 31, 2025
概括
在工人中,七天间歇性低巴性缺氧 (IHH) 暴露显著改变了身体质量指数 (BMI) 和相角 (PhA). 肠道微生物群也显示出显著的变化,而身体活动仍然很低.
科学领域:
- 生理学 生理学 生理学
- 人类生物学 人类生物学
- 环境健康 环境健康
背景情况:
- 已知间歇性低压性缺氧 (IHH) 诱导生理和代谢适应.
- 了解这些适应对于职业健康至关重要,特别是对于暴露于不同大气压力的工人来说.
研究的目的:
- 调查七天IHH暴露对营养状况,身体组成,肠道微生物群,运动强度和能量消耗的影响.
- 重新分析现有数据以澄清BMI和肠道细菌的显著变化.
主要方法:
- 使用了10名工人进行前后比较研究设计.
- 测量包括生物电阻分析 (BIA) 来测量身体组成和相角 (PhA),肠道微生物群的qPCR,以及体力活动的加速计.
- 统计分析涉及配对的t测试和威尔科克森签名等级测试.
主要成果:
- 观察到PHA显著增加 (p=0.0053) 和BMI显著下降 (p=0.0311).
- 在特定的肠道细菌家族中发现了显著的变化,包括生产酸盐的细菌 (p=0.037) 和乳酸菌种 (p=0.006).
- 在整个研究期间,身体活动水平始终保持在低水平.
结论:
- 重新分析表明,IHH暴露后BMI发生显著变化,与最初的报告相反.
- 暴露于IHH显著影响肠道微生物群的组成.
- 尽管暴露于IHH,但身体活动水平仍然很低,这表明需要进一步研究运动干预措施.
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