氧酸抑制高脂肪饮食促成的MC38-Syngeneic结肠直肠瘤通过胆酸重塑和微生物群调节抑制结肠直肠瘤生长
Jialing He1,2, Meng Duan1,2,3, Yuwen Shi1,2
1Department of Nutrition and Food Hygiene, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Disease, Hangzhou 310058, China.
Nutrients
|December 31, 2025
概括
氧化酸 (HDCA) 降低肥胖,并抑制小鼠的结直肠瘤生长. HDCA改变肠道微生物群,可能通过代谢途径影响瘤的发展.
科学领域:
- 代谢学 代谢学 代谢学
- 肠道微生物组研究研究
- 在瘤学瘤学.
背景情况:
- 肥胖是结直肠癌 (CRC) 的已知危险因素之一.
- 氧化胆酸 (HDCA) 在与肥胖相关的疾病,如非酒精性脂肪肝疾病 (NAFLD) 中显示出治疗潜力.
- HDCA对结直肠癌 (CRC) 的作用仍然未被探索,这表明了潜在的新疗法应用.
研究的目的:
- 在小鼠模型中研究氧化 (HDCA) 对肥胖和结直肠瘤生长的影响.
- 在肥胖和CRC的背景下,探索HDCA对宿主代谢和肠道微生物群组成的影响.
主要方法:
- 一种高脂肪饮食 (HFD) 补充了HDCA给C57BL/6小鼠.
- 通过注射MC38细胞建立了皮下结直肠癌 (CRC) 转移模型.
- 分析了体重,瘤体积,血液代谢物和肠道微生物群.
主要成果:
- 与HFD养的对照组相比,HDCA治疗减少了小鼠的皮下瘤体积.
- 代谢分析显示了胆汁分泌和脂质代谢途径的显著变化.
- HDCA显著改变了肠道微生物群的组成,降低了Chao1指数,改变了特定细菌系的相对丰度.
结论:
- 在小鼠中,HDCA的摄入改善了肥胖症,并抑制了结直肠瘤的生长.
- HDCA影响肠道微生物群,可以通过循环代谢变化来调解其抗瘤作用.
- HDCA为管理与肥胖相关的结直肠癌提供了潜在的治疗剂.
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