在β-Galactosidase研究的进步:从分子机制到酶输送系统的系统性审查
Márton Király1, Ádám Tibor Barna1, Nikolett Kállai-Szabó1,2
1Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary.
Pharmaceutics
|December 31, 2025
概括
β-银酸酶 (乳糖酶) 是医学和工业中的一个关键酶. 目前的口服输送方法显示出希望,但需要进一步的研究来提高酶稳定性和更广泛应用的成本效益.
科学领域:
- 生物技术和酶应用.
- 制药科学和药物输送
- 食品科学与技术 食品科学与技术
背景情况:
- β-银酸酶 (乳糖酶) 是一种关键的酶,在生物技术,食品生产和医学中发挥着重要作用.
- 它催化乳糖水解,对于乳糖不耐症治疗和无乳糖食品制造至关重要.
- 在优化β-银酸酶稳定性和经济有效的口服中仍然存在挑战.
研究的目的:
- 审查当前关于beta-galactosidase作为活性成分的知识.
- 为了总结可用的和文献中报告的β-galactosidase制剂.
- 探索Beta-galactosidase的口服药物输送系统的进展.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science进行了系统的文献搜索.
- 搜索的重点是关于beta-galactosidase口服药物配方的原始研究文章.
- 包括1895年至2025年间发表的研究.
主要成果:
- 在1633个初步结果中,选择了45个相关研究进行分析.
- 该审查确定了β-银酸酶的各种配方和应用.
- 目前的制剂提供治疗和工业上的好处.
结论:
- β-银酸酶是一种具有重要的工业和医学意义的多功能酶.
- 需要进一步创新口服输送系统,以提高效率,稳定性和成本效益.
- 本次审查突出了在口服药物输送中推进β-银酸酶应用的机会.
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