微针介导气体输送用于快速分离,增强药物透和联合治疗
Ziyang Zheng1, Ting Zhou1, Hongluo Li2
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
Pharmaceutics
|December 31, 2025
概括
微针 (MNs) 提供无痛药物输送,但气体辅助的微针系统可以增强药物透率,并允许快速分离以改善治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微针 (MNs) 是一个有前途的透皮药物递送系统,提供诸如避免第一通代谢和最少侵入性管理等优势.
- 传统的MN面临着诸如缓慢的尖端脱落和低于最佳的皮肤透射效率等局限性.
研究的目的:
- 审查微针介导的气体输送系统的最新进展.
- 探索加速MN尖端分离和增强毒品透的战略.
- 讨论各种气体的治疗潜力及其与先进疗法的MNs的组合.
主要方法:
- 系统审查关于微针技术和气体输送的文献.
- 对MN促进的气体输送机制进行分析,以改善分离和透.
- 在MN系统中评估不同气体 (H2,O2,NO,H2S,CO,CO2) 的治疗作用和协同效应.
主要成果:
- 气体辅助的MN系统显示出MN尖端与基础基板快速分离的潜力.
- 通过MN介导的气体输送观察到药物透率和输送效率的提高.
- 各种气体具有治疗效益,在组合疗法中可能产生协同效应.
结论:
- 气体辅助微针系统代表了通过皮肤递送药物的重大进步.
- 这些系统提供了提高效率,快速分离,并为联合治疗应用提供了潜力.
- 对气体辅助MNs的进一步研究有望用于治疗各种疾病.
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