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Updated: Jan 7, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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在肝硬化中使用全身PBPK方法治疗CYP2C19和CYP3A4代谢药物的药理动力学

Ruijing Mu1, Jingjing Gao1, Xiaoli Wang2

  • 1Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Pharmaceutics
|December 31, 2025
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,用于预测肝硬化中药物代谢的变化. 该模型成功地优化了通过CYP2C19和CYP3A4代谢的药物的剂量.

关键词:
在CYP2C19中.在 CYP3A4 中.剂量优化剂量优化肝硬化是肝硬化的一种疾病.药物动力学 药物动力学基于生理学的药物动力学模型.

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