破解皮肤屏障:驱动皮肤药物输送的模型和方法
Francelle Bouwer1, Marius Brits1, Joe M Viljoen1
1Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), Faculty of Health Sciences, North-West University, Building G16, Potchefstroom 2520, South Africa.
Pharmaceutics
|December 31, 2025
概括
皮肤药物输送面临着皮肤屏障挑战. 本综述探讨了研究皮肤透的各种模型和方法,强调了为有效的药物递送系统提供更好的预测工具的需要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤药物递送提供局部效果和改善服药性,但受到皮肤屏障特性,特别是角层 (SC) 的阻碍.
- 精确评估皮肤吸收和透性对于开发有效的局部和透皮疗法至关重要.
- 目前的模型和方法在预测体内性能的能力上有所不同,这对配方和监管批准提出了挑战.
研究的目的:
- 审查和比较用于研究皮肤药物吸收和透性的生物,合成和方法模型.
- 讨论不同模型和分析技术的优点,局限性和应用.
- 确定当前的挑战和未来的方向,以推进皮肤药物递送研究.
主要方法:
- 对各种模型的文献综述,包括ex vivo人体皮肤,动物模型 (猪皮,动物,子,子,蛇皮) 和合成替代品 (重建的人类表皮,Strat-M®膜).
- 分析创新方法,如扩散细胞,皮肤PAMPA,带剥离和先进的成像技术,以评估药物运输.
- 评估体外,外生和体内数据之间的相关性.
主要成果:
- 活体人体皮肤作为一个基准,但在可用性和道德上有局限性.
- 动物模型和合成替代品提供了不同程度的生理相关性和实用性的替代品.
- 先进的分析技术为药物透提供了定量和定性见解,有助于配方和生物等价性研究.
结论:
- 没有一个单一的模型可以完美地复制人体皮肤屏障功能,因此需要根据研究目标进行仔细的选择.
- 在将模型结果与体内结果相关联以及捕捉皮肤的动态性质方面,仍然存在挑战.
- 开发更具生理相关性的模型对于推进安全有效的皮肤药物递送系统至关重要.
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