自闭症相关的肠道微生物群衍生体Enterococcus facium调节小鼠肠脑轴功能和行为
Renzhen Ma1, Hidayat Ullah1,2, Fatemeh Shahbazi Bohlooli3
1Department of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian 116011, China.
Pathogens (Basel, Switzerland)
|December 31, 2025
概括
来自自闭症儿童的Enterococcus faecium在小鼠中诱导了焦虑,抑郁和社会缺陷. 这表明E. faecium可能会在自闭症谱系障碍 (ASD) 中破坏肠-大脑轴.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其致病源不明.
- 肠道微生物群的改变越来越多地与ASD有关.
- 菌在自闭症发展中的特殊作用需要研究.
研究的目的:
- 为了研究自闭症儿童的Enterococcus faecium对小鼠模型的影响.
- 评估由E. faecium暴露引起的行为,生理和神经变化.
主要方法:
- 在BALB/c小鼠口服E. faecium,持续30天.
- 行为测试 (开放场地,糖糖偏好,Y迷宫,社交互动).
- 对血清5-HT,结肠/大脑组织进行炎症和BBB完整性的分析,以及用于微生物群分析的便DNA测序.
主要成果:
- 在小鼠中,E. faecium诱导了焦虑,抑郁,记忆障碍和社会功能障碍.
- 观察到肠道损伤,炎症增加,紧结蛋白减少和粘素-2减少.
- 系统性炎症 (升高的LPS),肠道失调,神经损伤,以及大脑中血脑屏障完整性的损害.
结论:
- 自闭症患者的Enterococcus faecium可以在小鼠中诱导显著的行为和神经系统变化.
- 这些影响可能是由肠道微生物群失调,肠道屏障破坏和神经炎症介导的.
- E. faecium可能会导致自闭症谱系障碍的肠-大脑轴失调.
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